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The C1q-binding properties of donor specific antibodies (DSA) may be related to antibody-mediated rejection and poor outcome.We retrospectively studied 35 kidney transplant recipients with transplant glomerulopathy (TG) and de novo DSA (dnDSA). C1q dnDSA were measured in the serum stored at renal biopsy and the association among C1q-fixing dnDSA, C4d deposition and graft loss was examined.Of the 35...
Comparative analysis of the different subsets of CD4 + T-lymphocytes may provide hints on the immunologic mechanisms operating in the long-term fate of a kidney transplant.We analyzed peripheral regulatory CD4 + T cells (Tregs) and CD4 + cytotoxic T lymphocytes (CTLs) in antibody-mediated chronic rejection (AMCR), in middle-term kidney transplants (2–4years, MTKT) with good...
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