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We evaluated the anti-HIV-1 activity of an oligonucleotide derivative RKS-1443 in severe combined immunodeficient (SCID/beige) mice transplanted with normal human peripheral blood leukocytes (PBLs). The human chimeric mice were inoculated with HIV-1 CC1 three weeks after reconstitution and sacrificed two weeks later. Splenocytes were collected from the mice for determination of...
We have reported that the 5 -end-modified hexadeoxyribonucleotides (6mers), TGGGAG, have potent anti-HIV-1 activities in vitro. Among the 6mers bearing a variety of aralkyl groups at their 5 -ends, the 6mer bearing a 3,4-dibenzyloxybenzyl(DBB) group was most potent and furthermore showed less cytotoxicity. 1,2 5 -End-modification entailed substitution of the 5 -oxygen atom by...