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EPR studies have shown that water-soluble mononitrosyl iron complexes with N-methyl-d-glucamine dithiocarbamate (MNIC–MGD) (3μmol) injected to intact mice were decomposed virtually completely within 1h. The total content of MNIC–MGD in animal urine did not exceed 30nmol/ml. In the liver, a small amount of MNIC–MGD were converted into dinitrosyl iron complexes (30nmol/g of liver tissue). The same was...
The formation of protein-bound dinitrosyl–iron complexes (DNIC) in blood plasma and packed red cell fraction has been demonstrated by the EPR method in the experiments on rabbits which were i/v injected with the low-molecular DNIC with thiosulphate. This formation was ensured by transfer of Fe + (NO + ) 2 moieties from low-molecular DNIC onto serum albumin or hemoglobin molecules...
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