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We previously showed that peptides containing leptin sequences 1–33 or 61–90 are taken up by the rat brain. We now report the effects of these peptides on food intake and body weight in mature rats. Peptides were infused intravenously for 4weeks, using Alzet minipumps. Dosages were 20μg/kg/day in experiment I, and 60μg/kg/day in experiment 2. In experiment 1, female rats receiving peptides 1–33 and...
We studied the brain uptake of leptin and of a set of peptides whose combined sequences spanned the entire mature human leptin protein. We compared their uptake to that of albumin and IgG. Two of these peptides, consisting of residues 1–33 and 61–90, demonstrated brain uptake on a par with leptin protein itself, and significantly higher than the uptake of albumin and IgG. Further investigation revealed...
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