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This study examines the influence of circulating insulin-like growth factor-1 (IGF-1) and serum leptin on bone mass as well as modulation of bone mass during skeletal development. Moreover, an inverse relationship between IGF-1 and leptin is reported. To evaluate the effects of serum IGF-1 and serum leptin on bone mass in healthy postmenopausal women, and the possible role of IGF-1 in leptin production,...
In involutive osteoporosis the effects of bone active drugs on osteoblast and osteoclast functions may be evaluated by new bone markers. 1,25(OH)2D3 and chlorothiazide influence bone remodeling in spite of contrasting effects on urinary calcium excretion. Aim of present study was to investigate, by means of bone markers, the effects of 1,25(OH)2D3 and chlorothiazide on osteoblasts and osteoclasts...
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