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INTRODUCTION: Dopaminergic (DA) neurons in the ventral tegmental area (VTA) are key players in regulating motivation and learning. Such control is mediated by DA innervation of other brain regions, such as the nucleus accumbens (NAc) and the prefrontal cortex (PFC). AIM(S): With use of optogenetics we aimed to delineate if both electrophysiological activity of DA neurons and DA release in target brain...
Although morphine was previously reported to produce an instant induction of c-fos in the striatum, our recent studies have demonstrated that the expression of numerous immediate early genes (IEGs) is significantly elevated at delayed time-points (several hours) after morphine administration. To better dissect the time-course of opioid-produced IEG induction, we used in situ hybridization to examine...
Post‐traumatic stress disorder (PTSD) is an anxiety disorder that develops in predisposed individuals following a terrifying event. Studies on isogenic animal populations might explain susceptibility to PTSD by revealing associations between the molecular and behavioural consequences of traumatic stress. Our study employed four inbred mouse strains to search for differences in post‐stress response...
W artykule przedstawiono zarys podstawowych problemów związanych z parkowaniem w obszarach centralnych miasta. Zaprezentowano wyniki ankiety na temat satysfakcji, jakości i czasu parkowania w centrum Radomia.
Post-traumatic stress disorder (PTSD) is a chronic anxiety condition that develops as a result of a terrifying event. Clinical studies show that only about 10% of trauma-exposed people suffer from PTSD. Our research was focused on endophenotypes and molecular biomarkers of PTSD in an animal model. Differences in response to stress among inbred mouse strains (C57BL/6J, DBA/2J, SWR/J and 129P3/J) were...
Single morphine administration to mice leads to changes in the expression of numerous genes in mouse striatum. Among them are genes regulated by the glucocorticoid receptor activation, like Sgk1, Gilz and Plzf [Korostynski et al. (2007) Genome Biol]. Analysis of their expression patterns with the use of in situ hybridization revealed their different regional distribution throughout the brain. To verify...
The increased inclination to natural rewards like food and sensation seeking have been associated with elevated drug intake in humans. We aimed to compare four inbred mouse strains with known different susceptibility to drug addiction in respect to response to natural rewards. In this study, we investigated four inbred strains C57Bl/6J, DBA/2J, SWR/J and 129P3/J in the selfadministration of food (SAF)...
The brain’s noradrenergic system system provides essential modulation to neuronal activity, with well established roles in control of arousal and selective attention, as well as memory, learning and response to stress. We have generated a transgenic mouse, NR1DbhCre, with ablation of the essential NMDA receptor subunit NR1 (Grin1) in noradrenergic cells. Since no functional NMDA receptors may be formed...
The noradrenergic system of the brain has been postulated to mediate arousal, selective attention, as well as anxiety, depression and learning and memory. Here we report the behavioral phenotype of transgenic mouse (NR1DbhCre) with selective ablation of the NMDA receptor subunit NR1 in noradrenergic cells. We focused on behaviors modulated by the noradrenergic system, in particular anxiety-like behaviors...
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