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Among naphthoquinones, lapachol and many heterocyclic derivatives have been investigated during the past years, mainly due to their antibacterial, antifungal and anticancer activities. Assessment of possible incompatibility between an active component (i.e. lapachol) and different excipients along with the evaluation of thermal stability are crucial parts of a normal study prior to the final formulation...
Infections caused by protozoa of the genus Leishmania are a major worldwide health problem, with high endemicity in developing countries. The incidence of the disease has increased since the emergence of AIDS. In the absence of a vaccine, there is an urgent need for effective drugs to replace/supplement those in current use. The plant kingdom is undoubtedly valuable as a source of new medicinal agents...
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