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Invasion of host cells is essential for the pathogenicity of Toxoplasma gondii. This review examines the signal transduction pathways that lead to the internalization of T. gondii. We demonstrate that extra- and intracellular Ca 2+ mobilization, Ca 2+ -calmodulin complex and phospholipase A 2 activities are required for T. gondii entry. T. gondii also causes the activation...