Search results for: Matthew J. Bizzarro

Items from 1 to 14 out of 14 results

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Is Extracorporeal Membrane Oxygenation for a Neonate Ever Ethically Obligatory?

Steven M. Peterec, Matthew J. Bizzarro, Mark R. Mercurio

The Journal of Pediatrics > 2018 > 195 > C > 297-301

Certain interventions in the neonatal intensive care unit are considered ethically obligatory, and should be provided over parental objections. After reviewing a case, comparative outcome data, and relevant ethical principles, we propose that extracorporeal membrane oxygenation for meconium aspiration syndrome may, in some cases, be an ethically obligatory treatment.

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Central line-associated bloodstream infections in the NICU: Successes and controversies in the quest for zero

Renée E. Mobley, Matthew J. Bizzarro

Seminars in Perinatology > 2017 > 41 > 3 > 166-174

Central line-associated bloodstream infections (CLABSI) are among the most common healthcare-acquired infections in the neonatal intensive care unit (NICU) population and are associated with an increased risk of morbidity and mortality, as well as increased healthcare costs, and duration of hospitalization. Over the past decade, numerous local, statewide, and national quality improvement initiatives...

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Oral Alimentation in Neonatal and Adult Populations Requiring High-Flow Oxygen via Nasal Cannula

Steven B. Leder, Jonathan M. Siner, Matthew J. Bizzarro, Brian M. McGinley, more

Dysphagia > 2016 > 31 > 2 > 154-159

Use of high-flow oxygen via nasal cannula (HFO₂-NC) is increasingly common in intensive care unit (ICU) settings. Despite the critical interface between respiration and swallowing, and the high acuity of patients in ICUs, the impact of HFO₂-NC on feeding and swallowing is unknown. The present prospective, single-center, cohort study investigated the impact of HFO₂-NC use on oral alimentation in neonatal...

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Neonatal Sepsis 2004-2013: The Rise and Fall of Coagulase-Negative Staphylococci

Matthew J. Bizzarro, Veronika Shabanova, Robert S. Baltimore, Louise-Marie Dembry, more

The Journal of Pediatrics > 2015 > 166 > 5 > 1193-1199

To evaluate data for the period 2004-2013 to identify changes in demographics, pathogens, and outcomes in a single, level IV neonatal intensive care unit.Sepsis episodes were identified prospectively and additional information obtained retrospectively from infants with sepsis while in the neonatal intensive care unit from 2004 to 2013. Demographics, hospital course, and outcome data were collected...

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Ear drainage and the role of sepsis evaluations in the neonatal intensive care unit

Mona Khattab, Charlene Cannon‐Heinrich, Matthew J. Bizzarro

Acta Paediatrica > 103 > 7 > 732 - 736

AimTo design and implement an intervention to reduce ear drainage and subsequent sepsis evaluation and treatment in the neonatal intensive care unit. MethodsFrom 2008 to 2011, we observed an increase in the rates of ear drainage warranting investigation. Data collection was performed from 1991 to 2013 on 50 cases. Preliminary analysis revealed an association between timing of endotracheal tube tape...

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Concurrent Bloodstream Infections in Infants with Necrotizing Enterocolitis

Matthew J. Bizzarro, Richard A. Ehrenkranz, Patrick G. Gallagher

The Journal of Pediatrics > 2014 > 164 > 1 > 61-66

To determine the incidence, microbiology, risk factors, and outcomes related to bloodstream infections (BSIs) concurrent with the onset of necrotizing enterocolitis (NEC).We performed a retrospective review of all cases of NEC in a single center over 20 years. BSI was categorized as “NEC-associated” if it occurred within 72 hours of the diagnosis of NEC and “post-NEC” if it occurred >72 hours afterwards...

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Novel FOXF1 Deep Intronic Deletion Causes Lethal Lung Developmental Disorder, Alveolar Capillary Dysplasia with Misalignment of Pulmonary Veins

Przemyslaw Szafranski, Yaping Yang, Melissa U. Nelson, Matthew J. Bizzarro, more

Human Mutation > 34 > 11 > 1467 - 1471

Haploinsufficiency of FOXF1 causes an autosomal dominant neonatally lethal lung disorder, alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV). We identified novel 0.8‐kb deletion within the 1.4‐kb intron of FOXF1 in a deceased newborn diagnosed with ACDMPV. The deletion arose de novo on the maternal copy of the chromosome 16, and did not affect FOXF1 minigene splicing tested...

article

Introduction

Matthew J. Bizzarro

Seminars in Perinatology > 2012 > 36 > 6 > 407

article

Health Care–Associated Infections in the Neonatal Intensive Care Unit: Barriers to Continued Success

Matthew J. Bizzarro

Seminars in Perinatology > 2012 > 36 > 6 > 437-444

Health care–associated infections often result in significant morbidity and mortality to affected patients and substantial financial cost to an overburdened health care system. Local, statewide, and national efforts have been conducted to eradicate central line–associated infections, ventilator-associated pneumonia, and urinary tract infections from inpatient and outpatient facilities. In the neonatal...

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Antibiotic Exposure in the Newborn Intensive Care Unit and the Risk of Necrotizing Enterocolitis

Vanaja N. Alexander, Veronika Northrup, Matthew J. Bizzarro

The Journal of Pediatrics > 2011 > 159 > 3 > 392-397

To determine whether duration of antibiotic exposure is an independent risk factor for necrotizing enterocolitis (NEC).A retrospective, 2:1 control-case analysis was conducted comparing neonates with NEC to those without from 2000 through 2008. Control subjects were matched on gestational age, birth weight, and birth year. In each matched triad, demographic and risk factor data were collected from...

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The Impact of Environmental and Genetic Factors on Neonatal Late-Onset Sepsis

Matthew J. Bizzarro, Yuan Jiang, Naveed Hussain, Jeffrey R. Gruen, more

The Journal of Pediatrics > 2011 > 158 > 2 > 234-238.e1

To assess the genetic contribution to late-onset sepsis in twins in the newborn intensive care unit.A retrospective cohort analysis of twins born from 1994 to 2009 was performed on data collected from the newborn intensive care units at Yale University and the University of Connecticut. Sepsis concordance rates were compared between monozygotic and dizygotic twins. Mixed-effects logistic regression...

article

COL4A1 Mutation in Preterm Intraventricular Hemorrhage

Kaya Bilguvar, Michael L. DiLuna, Matthew J. Bizzarro, Yasar Bayri, more

The Journal of Pediatrics > 2009 > 155 > 5 > 743-745

Intraventricular hemorrhage is a common complication of preterm infants. Mutations in the type IV procollagen gene, COL4A1, are associated with cerebral small vessel disease with hemorrhage in adults and fetuses. We report a rare variant in COL4A1 associated with intraventricular hemorrhage in dizygotic preterm twins. These results expand the spectrum of diseases attributable to mutations in type...

article

Necrotizing Enterocolitis in Newborns

Alecia M. Thompson, Matthew J. Bizzarro

Drugs > 2008 > 68 > 9 > 1227-1238

Necrotizing enterocolitis (NEC) is primarily a disease process of the gastrointestinal (GI) tract of premature neonates that results in inflammation and bacterial invasion of the bowel wall. Despite advances in the care of premature infants, NEC remains one of the leading causes of morbidity and mortality in this population. It occurs in 1–5% of all neonatal intensive care admissions and 5–10% of...

article

Antibiotic-Resistant Organisms in the Neonatal Intensive Care Unit

Matthew J. Bizzarro, Patrick G. Gallagher

Seminars in Perinatology > 2007 > 31 > 1 > 26-32

Neonates, particularly those born prematurely, are at an increased risk of bacterial infection. Empiric treatment with antimicrobials occurs frequently in the neonatal intensive care unit (NICU). Repeated and/or prolonged courses of antibiotic exposure have resulted in an increase in the prevalence of hospital-acquired, antibiotic-resistant organisms such as methicillin-resistant Staphylococcus aureus,...

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