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Oxygen beams are high linear energy transfer (LET) radiation characterized by higher relative biological effectiveness than low LET radiation. The aim of the current study was to determine the signaling differences between γ- and oxygen ion-irradiation. Activation of various signaling molecules was looked in A549 lung adenocarcinoma cells irradiated with 2Gy oxygen, 2Gy or 6Gy γ-radiation. Oxygen...
Chinese hamster V79 cells were exposed to high LET (linear energy transfer) 16 O-beam (625keV/μm) radiation in the dose range of 0–9.83Gy. Cell survival, micronuclei (MN), chromosomal aberrations (CA) and induction of apoptosis were studied as a follow up of our earlier study on high LET radiations ( 7 Li-beam of 60keV/μm and 12 C-beam of 295keV/μm) as well as 60 Co...
Chinese hamster V79 cell and a cell strain M5, derived from V79 cells and reported to be relatively resistant to γ-ray, hydrogen peroxide, and N-methyl-N-nitro-N-nitrosoguanidine (MNNG; a potent human carcinogen), were exposed to high LET 7 Li-beam (LET=60keV/μm) at ∼90% confluent state in the dose range of 0–1Gy. Effects of 7 Li-beam exposure on cell survival, micronuclei induction...
Archaea are expected to be highly repair proficient since they survived the vicious onslaught of radiation damage at the time of their early appearance. The DNA double strand break repairing ability of mesophilic archaea Methanosarcina barkeri (DSM 804) was studied using 7 Li, 12 C and 16 O heavy ions and compared with that of 60 Co γ-rays. They can repair...
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