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Results from previous studies from our laboratory have shown that T cells obtained from the spleens of C57BL/6 mice that consumed ethanol chronically have increased expression of activation markers and increased second signal-independent production of interferon-gamma (IFN-γ). We now report that in vitro-activated CD11b + splenocytes obtained from C57BL/6 and BALB/c mice that consumed ethanol...
Patients with chronic inflammatory diseases, including Crohn's disease and rheumatoid arthritis, as well as those with certain viral infections, and patients who are transplant recipients or who have certain hematologic malignancies have been observed to have CD57 + T cell expansion in both CD4 + and CD8 + subsets. We have reported previously that alcoholic patients also have...
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