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Drugs modulating the ATP-sensitive potassium (KATP) channel activity are widely used for the treatment of diabetes mellitus, the target being pancreatic β-cells. However, any cell type possessing KATP channels might be concomitantly affected. We investigated the metabolic effect of glibenclamide, a KATP channel closer, and/or diazoxide, a KATP channel opener, on total intracellular content of calcium...
We describe two splenectomized patients admitted with pneumonia. The course in one was complicated by overwhelming multiorgan failure when the only indicative laboratory result was seropositivity for Legionella hackeliae and Legionella longbeachae. He was initially treated with ceftriaxone and roxithromycin, followed by levofloxacin as well as intensive supportive treatment, and survived. The second...
We describe two patients with acute leukaemia who died of massive haemoptysis caused by invasive pulmonary aspergillosis (IPA). The fatal event occurred during the period of bone marrow remission which followed chemotherapy-induced neutropenia. This is a rare complication. We were able to find additional 17 similar cases in the English literature, which we review.Clinically, the picture consisted...
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