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Genome-wide identification of transcription factor binding sites (TFBSs) is critical for understanding transcriptional regulation of the gene expression network. ChIP-chip experiments accelerate the procedure of mapping target TFBSs for diverse cellular conditions. We address the problem of discriminating potential TFBSs in ChIP-enriched regions from those of non ChIP-enriched regions using ensemble...
Ribonuclease L (RNase L) is an antiviral endoribonuclease that cleaves hepatitis C virus (HCV) RNA at single-stranded UA and UU dinucleotides throughout the open reading frame (ORF). To determine whether RNase L exerts evolutionary pressure on HCV we examined the frequencies of UA and UU dinucleotides in 162 RNA sequences from the Los Alamos National Labs HCV Database (http://hcv.lanl.gov). Considering...
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