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We present the results of next-generation sequencing (NGS) based HLA typing, using paired blood and saliva samples to demonstrate that typing results are independent of tissue source. We show that NGS reads from whole-genome sequencing (WGS) reads are also suitable for HLA typing, similarly to reads produced by well-targeted HLA kits albeit with lower precision.Both saliva and blood samples were collected...
In recent years, GDNF has emerged as a protective and restorative agent in several models of neurodegeneration; however, the exact molecular mechanisms responsible for these effects are not yet fully understood. Here we examined the effects of astrocytes secreting GDNF on neurons subjected to 6OHDA toxicity using in vitro neuron-astroglia co-cultures. Astrocytes were transduced with lentiviral vectors...
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