Search results for: Boris Zhivotovsky

Items from 1 to 20 out of 89 results

article

2‐Deoxy‐D‐glucose has distinct and cell line‐specific effects on the survival of different cancer cells upon antitumor drug treatment

Polina Maximchik, Alibek Abdrakhmanov, Evgeniya Inozemtseva, Pyotr A. Tyurin‐Kuzmin, more

The FEBS Journal > 285 > 24 > 4590 - 4601

The dependence of tumors on glycolysis for ATP generation offers a rationale for therapeutic strategies aimed at selective inhibition of the glycolytic pathway. Analysis of tumor cell responses to anticancer drugs revealed that inhibition of glycolysis by 2‐deoxy‐D‐glucose (2‐DG) generally augmented the apoptotic response; however, in HCT116 human colon carcinoma cells, apoptosis was suppressed. A...

article

Alterations in the nucleocytoplasmic transport in apoptosis: Caspases lead the way

Gelina S. Kopeina, Evgeniia A. Prokhorova, Inna N. Lavrik, Boris Zhivotovsky

Cell Proliferation > 51 > 5 > n/a - n/a

Apoptosis is a mode of regulated cell death that is indispensable for the morphogenesis, development and homeostasis of multicellular organisms. Caspases are cysteine‐dependent aspartate‐specific proteases, which function as initiators and executors of apoptosis. Caspases are cytosolic proteins that can cleave substrates located in different intracellular compartments during apoptosis. Many years...

article

Caspase-2 is a negative regulator of necroptosis

Alexey V. Zamaraev, Gelina S. Kopeina, Jörn H. Buchbinder, Boris Zhivotovsky, more

The International Journal of Biochemistry & Cell Biology > 2018 > 102 > C > 101-108

The role of caspase-2 in cell death regulation remains largely unknown. In this study we have analyzed the involvement of caspase-2 in RIPK1-regulated necrosis (necroptosis) in human ovarian carcinoma cells. We show that these cells undergo necroptosis upon treatment with the DNA damaging drug cisplatin in combination with the pan-caspase inhibitor zVAD-fmk. Downregulation of caspase-2 leads to an...

article

Modulation of Mcl-1 transcription by serum deprivation sensitizes cancer cells to cisplatin

Viacheslav V. Senichkin, Gelina S. Kopeina, Eugeniia A. Prokhorova, Alexey V. Zamaraev, more

Biochimica et Biophysica Acta (BBA) - General Subjects > 2018 > 1862 > 3 > 557-566

The development of approaches that increase therapeutic effects of anti-cancer drugs is one of the most important tasks of oncology. Caloric restriction in vivo or serum deprivation (SD) in vitro has been shown to be an effective tool for sensitizing cancer cells to chemotherapeutic drugs. However, the detailed mechanisms underlying the enhancement of apoptosis in cancer cells by SD remain to be elucidated...

article

Post-translational Modification of Caspases: The Other Side of Apoptosis Regulation

Alexey V. Zamaraev, Gelina S. Kopeina, Evgeniia A. Prokhorova, Boris Zhivotovsky, more

Trends in Cell Biology > 2017 > 27 > 5 > 322-339

Apoptosis is a crucial program of cell death that controls development and homeostasis of multicellular organisms. The main initiators and executors of this process are the Cysteine-dependent ASPartate proteASES – caspases. A number of regulatory circuits tightly control caspase processing and activity. One of the most important, yet, at the same time still poorly understood control mechanisms of...

article

Contrasting effects of glutamine deprivation on apoptosis induced by conventionally used anticancer drugs

Kadri Valter, Lian Chen, Björn Kruspig, Polina Maximchik, more

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research > 2017 > 1864 > 3 > 498-506

Tumor cells dependence on glutamine offers a rationale for their elimination via targeting of glutamine metabolism. The aim of this work was to investigate how glutamine deprivation affects the cellular response to conventionally used anticancer drugs. To answer this question, neuroblastoma cells were pre-incubated in a glutamine-free medium and treated with cisplatin or etoposide. Obtained results...

article

Mitophagy: Link to cancer development and therapy

Andrey V. Kulikov, Ekaterina A. Luchkina, Vladimir Gogvadze, Boris Zhivotovsky

Biochemical and Biophysical Research Communications > 2017 > 482 > 3 > 432-439

Mitophagy, the selective degradation of mitochondria via the autophagic pathway, is a vital mechanism of mitochondrial quality control in cells. Mitophagy is responsible for the removal of malfunctioning or damaged mitochondria, which is essential for normal cellular physiology and tissue development. Pathways involved in the regulation of mitophagy, tumorigenesis, and cell death are overlapping in...

article

Caloric restriction - A promising anti-cancer approach: From molecular mechanisms to clinical trials

Gelina S. Kopeina, Vyacheslav V. Senichkin, Boris Zhivotovsky

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer > 2017 > 1867 > 1 > 29-41

Cancer is the second leading cause of death worldwide and the morbidity is growing in developed countries. According to WHO, >14 million people per year are diagnosed with cancer and about 8 million die. Anti-cancer strategy includes chemo-, immune- and radiotherapy or their combination. Unfortunately, these widely used strategies often have insufficient efficacy and significant toxic effects on...

article

Reactive oxygen species regulate a balance between mitotic catastrophe and apoptosis

Irina V. Sorokina, Tatiana V. Denisenko, Gabriela Imreh, Vladimir Gogvadze, more

The International Journal of Biochemistry & Cell Biology > 2016 > 81 > PA > 133-136

Mitotic catastrophe (MC) is a sequence of events resulting from premature or inappropriate entry of cells into mitosis that can be caused by chemical or physical stresses. There are several observations permitting to define MC as an oncosuppressive mechanism. MC can end up in apoptosis, necrosis or senescence. Here we show that the anticancer drug doxorubicin triggers DNA damage and MC independently...

chapter

Systems Biology Analysis of Cell Death Pathways in Cancer: How Collaborative and Interdisciplinary Research Helps

Boris Zhivotovsky

Cancer Systems Biology, Bioinformatics and Medicine > Bioinformatics and Systems Biology Analysis > 267-296

Programmed cell death, together with proliferation and differentiation, is responsible for maintaining the population of cells in all tissues. Dysregulation in this genetically-regulated process plays an important role in the pathophysiology of different disorders. Excessive cell death is pathogenic when it concerns post-mitotic cells and results in various diseases, such as infarction, stroke or...

article

Targeting succinate:ubiquinone reductase potentiates the efficacy of anticancer therapy

Björn Kruspig, Kadri Valter, Belma Skender, Boris Zhivotovsky, more

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research > 2016 > 1863 > 8 > 2065-2071

Mitochondria play a pivotal role in apoptosis: permeabilization of the outer mitochondrial membrane and the release of pro-apoptotic proteins from the intermembrane space of mitochondria are regarded as the key event in apoptosis induction. Here we demonstrate how non-toxic doses of the mitochondrial Complex II inhibitor thenoyltrifluoroacetone (TTFA), which specifically inhibits the ubiquinone-binding...

article

Mitotic catastrophe and cancer drug resistance: A link that must to be broken

Tatiana V. Denisenko, Irina V. Sorokina, Vladimir Gogvadze, Boris Zhivotovsky

Drug Resistance Updates > 2016 > 24 > C > 1-12

An increased tendency of genomic alterations during the life cycle of cells leads to genomic instability, which is a major driving force for tumorigenesis. A considerable fraction of tumor cells are tetraploid or aneuploid, which renders them intrinsically susceptible to mitotic aberrations, and hence, are particularly sensitive to the induction of mitotic catastrophe. Resistance to cell death is...

article

Calcium and mitochondria in the regulation of cell death

Sten Orrenius, Vladimir Gogvadze, Boris Zhivotovsky

Biochemical and Biophysical Research Communications > 2015 > 460 > 1 > 72-81

The calcium ion has long been known to play an important role in cell death regulation. Hence, necrotic cell death was early associated with intracellular Ca²⁺ overload, leading to mitochondrial permeability transition and functional collapse. Subsequent characterization of the signaling pathways in apoptosis revealed that Ca²⁺/calpain was critically involved in the processing of the mitochondrially...

article

Role of the nucleus in apoptosis: signaling and execution

Evgeniia A. Prokhorova, Alexey V. Zamaraev, Gelina S. Kopeina, Boris Zhivotovsky, more

Cellular and Molecular Life Sciences > 2015 > 72 > 23 > 4593-4612

Since their establishment in the early 1970s, the nuclear changes upon apoptosis induction, such as the condensation of chromatin, disassembly of nuclear scaffold proteins and degradation of DNA, were, and still are, considered as the essential steps and hallmarks of apoptosis. These are the characteristics of the execution phase of apoptotic cell death. In addition, accumulating data clearly show...

article

Cell death controlling complexes and their potential therapeutic role

Alexey V. Zamaraev, Gelina S. Kopeina, Boris Zhivotovsky, Inna N. Lavrik

Cellular and Molecular Life Sciences > 2015 > 72 > 3 > 505-517

Programmed cell death plays a central role in the regulation of homeostasis and development of multicellular organisms. Deregulation of programmed cell death is connected to a number of disorders, including cancer and autoimmune diseases. Initiation of cell death occurs in the multiprotein complexes or high molecular weight platforms. Composition, structure, and molecular interactions within these...

article

Mitochondrial substrates in cancer: Drivers or passengers?

Björn Kruspig, Boris Zhivotovsky, Vladimir Gogvadze

Mitochondrion > 2014 > 19 > Part A > 8-19

The majority of cancers demonstrate various tumor-specific metabolic aberrations, such as increased glycolysis even under aerobic conditions (Warburg effect), whereas mitochondrial metabolic activity and their contribution to cellular energy production are restrained. One of the most important mechanisms for this metabolic switch is the alteration in the abundance, utilization, and localization of...

article

Mitochondria — a bullseye in cancer therapy

Vladimir Gogvadze, Boris Zhivotovsky

Mitochondrion > 2014 > 19 > Part A > 1-2

article

miRNAs in lung cancer: A link to aging

Anna Zagryazhskaya, Boris Zhivotovsky

Ageing Research Reviews > 2014 > 17 > Complete > 54-67

Lung cancer is a leading cause of cancer deaths worldwide. Development of lung cancer is associated with exposure to carcinogens such as tobacco smoke and some environmental factors. The incidence of lung cancer increases with age, particularly after age 60. It was estimated that less than 2% of all lung cancer cases occurred in patients younger than 45; therefore, this type of tumor can be considered...

article

Targeting mitochondria by α-tocopheryl succinate overcomes hypoxia-mediated tumor cell resistance to treatment

Andrey V. Kulikov, Alexander S. Vdovin, Boris Zhivotovsky, Vladimir Gogvadze

Cellular and Molecular Life Sciences > 2014 > 71 > 12 > 2325-2333

Rapidly proliferating tumor cells easily become hypoxic. This results in acquired stability towards treatment with anticancer drugs. Here, we show that cells grown at 0.1 % oxygen are more resistant towards treatment with the conventionally used anticancer drugs doxorubicin and cisplatin. The stimulation of apoptosis, as assessed by the number of cells in the SubG1 fraction of the cell cycle, release...

article

Corrigendum to: “Mitochondrial targeting of α-tocopheryl succinate enhances its pro-apoptotic efficacy: A new paradigm for effective cancer therapy” [Free Radic Biol Med. 50 (2011) 1546–1555]

Lan-Feng Dong, Victoria J.A. Jameson, David Tilly, Lubomir Prochazka, more

Free Radical Biology and Medicine > 2013 > 65 > C > 895-896

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INFONA - science communication portal

Search results for: Boris Zhivotovsky

2‐Deoxy‐D‐glucose has distinct and cell line‐specific effects on the survival of different cancer cells upon antitumor drug treatment

Alterations in the nucleocytoplasmic transport in apoptosis: Caspases lead the way

Caspase-2 is a negative regulator of necroptosis

Modulation of Mcl-1 transcription by serum deprivation sensitizes cancer cells to cisplatin

Post-translational Modification of Caspases: The Other Side of Apoptosis Regulation

Contrasting effects of glutamine deprivation on apoptosis induced by conventionally used anticancer drugs

Mitophagy: Link to cancer development and therapy

Caloric restriction - A promising anti-cancer approach: From molecular mechanisms to clinical trials

Reactive oxygen species regulate a balance between mitotic catastrophe and apoptosis

Systems Biology Analysis of Cell Death Pathways in Cancer: How Collaborative and Interdisciplinary Research Helps

Targeting succinate:ubiquinone reductase potentiates the efficacy of anticancer therapy

Mitotic catastrophe and cancer drug resistance: A link that must to be broken

Calcium and mitochondria in the regulation of cell death

Role of the nucleus in apoptosis: signaling and execution

Cell death controlling complexes and their potential therapeutic role

Mitochondrial substrates in cancer: Drivers or passengers?

Mitochondria — a bullseye in cancer therapy

miRNAs in lung cancer: A link to aging

Targeting mitochondria by α-tocopheryl succinate overcomes hypoxia-mediated tumor cell resistance to treatment

Corrigendum to: “Mitochondrial targeting of α-tocopheryl succinate enhances its pro-apoptotic efficacy: A new paradigm for effective cancer therapy” [Free Radic Biol Med. 50 (2011) 1546–1555]

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