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A new approach utilizing multiple infusion start times for two stable isotopes of leucine was applied to seven pregnancies in order to assess equilibration times for isotopic studies when a single fetal blood sample is available.Two infusates, one containing l -[1-13C]-leucine and the other l -[5,5,5-D3]-leucine, were given as a primed constant infusion in the maternal circulation at fetal blood sampling...
Introduction: In ovine pregnancy, there is an interorgan cycling of glutamine and glutamate between the fetal liver and placenta. The fetal liver has a net production of glutamate that is extracted almost completely from the fetal circulation by the placenta. Conversely, glutamine is released by the placenta into the umbilical vein and taken up by the fetal liver. In late gestation approximately...
Objective: To assess fetal maternal leucine relationships in AGA and IUGR fetuses at the time of fetal blood sampling (FBS).Study Design: A maternal primed, constant infusion of L[1- 13 C]Leucine was given in 4 AGA and 13 IUGR pregnancies. IUGR pregnancies were divided according to velocimetry in the umbilical artery (PI) and to fetal heart rate (FHR) into: Group 1, normal FHR and PI,...
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