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Prostaglandin F 2alpha (PGF 2α ) and interleukin-1beta (IL-1β) levels are elevated in inflamed dental pulp. The roles of IL-1β and PGF 2α in the pathogenesis of pulpal inflammation await investigation. We found that IL-1β stimulated PGF 2α production of human dental pulp cells. IL-1β and PGF 2α (0.5–10 μmol/L) also induced IL-8 production and mRNA expression...
Butyrate is a metabolite produced by oral and colonic microorganism. Butyrate has been shown to reduce colon cancer, whereas its role in oral carcinogenesis is not clear. Butyrate concentration in dental plaque and saliva ranged from 0.2 to 16mM. In this study, we found that sodium butyrate inhibited the growth of SAS tongue cancer cells by 32% and 53% at concentrations of 1 and 2mM, respectively...
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