Search results for: Maureen A. Sartor

Items from 1 to 17 out of 17 results

article

Significant association between host transcriptome‐derived HPV oncogene E6* influence score and carcinogenic pathways, tumor size, and survival in head and neck cancer

Tingting Qin, Lada A. Koneva, Yidan Liu, Yanxiao Zhang, more

Background Human papillomavirus (HPV) oncogenes E6, E7, and shorter isoforms of E6 (E6*) are known carcinogenic factors in head and neck squamous cell carcinoma (HNSCC). Little is known regarding E6* functions. Methods We analyzed RNA‐seq data from 68 HNSCC HPV type 16‐positive tumors to determine host genes and pathways associated with E6+E7 expression (E6E7) or the percent of full‐length E6 (E6%FL)...

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Mono-2-ethylhexyl phthalate disrupts neurulation and modifies the embryonic redox environment and gene expression

Karilyn E. Sant, Dana C. Dolinoy, Joseph L. Jilek, Maureen A. Sartor, more

Reproductive Toxicology > 2016 > 63 > C > 32-48

Mono-2-ethylhexl phthalate (MEHP) is the primary metabolite of di-2-ethylhexyl phthalate (DEHP), a ubiquitous contaminant in plastics. This study sought to determine how structural defects caused by MEHP in mouse whole embryo culture were related to temporal and spatial patterns of redox state and gene expression. MEHP reduced morphology scores along with increased incidence of neural tube defects...

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Epigenome‐wide DNA methylation analysis implicates neuronal and inflammatory signaling pathways in adult murine hepatic tumorigenesis following perinatal exposure to bisphenol A

Caren Weinhouse, Maureen A. Sartor, Christopher Faulk, Olivia S. Anderson, more

Environmental and Molecular Mutagenesis > 57 > 6 > 435 - 446

Developmental exposure to the endocrine‐active compound bisphenol A (BPA) has been linked to epigenotoxic and potential carcinogenic effects in rodent liver, prostate, and mammary glands. A dose‐dependent increase in hepatic tumors in 10‐month mice perinatally exposed to one of three doses of BPA (50 ng, 50 µg, or 50 mg BPA/kg chow) was previously reported. These tumors represent early‐onset disease...

article

Stability of methylation markers in head and neck squamous cell carcinoma

Shama Virani, Emily Light, Lisa A. Peterson, Maureen A. Sartor, more

Head & Neck > 38 > S1 > E1325 - E1331

Background As cancer progresses, methylation patterns change to promote the tumorigenic phenotype. However, stability of methylation markers over time and the extent that biopsy samples are representative of larger tumor specimens are unknown. This information is critical for clinical use of such biomarkers. Methods Ninety‐eight patients with tumor specimens from 2 timepoints were measured for...

article

A Mouse Model of X-linked Intellectual Disability Associated with Impaired Removal of Histone Methylation

Shigeki Iwase, Emily Brookes, Saurabh Agarwal, Aimee I. Badeaux, more

Cell Reports > 2016 > 14 > 5 > 1000-1009

Mutations in a number of chromatin modifiers are associated with human neurological disorders. KDM5C, a histone H3 lysine 4 di- and tri-methyl (H3K4me2/3)-specific demethylase, is frequently mutated in X-linked intellectual disability (XLID) patients. Here, we report that disruption of the mouse Kdm5c gene recapitulates adaptive and cognitive abnormalities observed in XLID, including impaired social...

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Transcriptomic profiling of curcumin-treated human breast stem cells identifies a role for stearoyl-coa desaturase in breast cancer prevention

Justin A. Colacino, Sean P. McDermott, Maureen A. Sartor, Max S. Wicha, more

Breast Cancer Research and Treatment > 2016 > 158 > 1 > 29-41

Curcumin is a potential agent for both the prevention and treatment of cancers. Curcumin treatment alone, or in combination with piperine, limits breast stem cell self-renewal, while remaining non-toxic to normal differentiated cells. We paired fluorescence-activated cell sorting with RNA sequencing to characterize the genome-wide changes induced specifically in normal breast stem cells following...

article

NDN and CD1A are novel prognostic methylation markers in patients with head and neck squamous carcinomas

Shama Virani, Emily Bellile, Carol R. Bradford, Thomas E. Carey, more

BMC Cancer > 2015 > 15 > 1 > 1-13

Background HPV-associated HNSCCs have a distinct etiologic mechanism and better prognosis than those with non-HPV associated HNSCCs. However, even within the each group, there is heterogeneity in survival time. Here, we test the hypothesis that specific candidate gene methylation markers (CCNA1, NDN, CD1A, DCC, p16, GADD45A) are associated with tumor recurrence and survival, in a well-characterized,...

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Bisphenol A‐associated alterations in the expression and epigenetic regulation of genes encoding xenobiotic metabolizing enzymes in human fetal liver

Muna S. Nahar, Jung H. Kim, Maureen A. Sartor, Dana C. Dolinoy

Environmental and Molecular Mutagenesis > 55 > 3 > 184 - 195

Alterations in xenobiotic metabolizing enzyme (XME) expression across the life course, along with genetic, nutritional, and environmental regulation, can influence how organisms respond to toxic insults. In this study, we investigated the hypothesis that in utero exposure to the endocrine active compound, bisphenol A (BPA), influences expression and epigenetic regulation of phase I and II XME genes...

article

Identification of a NF-κB cardioprotective gene program: NF-κB regulation of Hsp70.1 contributes to cardioprotection after permanent coronary occlusion

Michael E. Wilhide, Michael Tranter, Xiaoping Ren, Jing Chen, more

Journal of Molecular and Cellular Cardiology > 2011 > 51 > 1 > 82-89

The transcription factor Nuclear Factor Kappa B (NF-κB) has been shown to be cardioprotective after permanent coronary occlusion (PO) and late ischemic preconditioning (IPC), and yet it is cell injurious after ischemia/reperfusion (I/R) in the heart. There is limited information regarding NF-κB-dependent cardioprotection, and the NF-κB-dependent genes that contribute to the cardioprotection after...

article

NF-κB driven cardioprotective gene programs; Hsp70.3 and cardioprotection after late ischemic preconditioning

Michael Tranter, Xiaoping Ren, Tiffany Forde, Michael E. Wilhide, more

Journal of Molecular and Cellular Cardiology > 2010 > 49 > 4 > 664-672

It has been shown that the transcription factor NF-κB is necessary for late phase cardioprotection after ischemic preconditioning (IPC) in the heart, and yet is injurious after ischemia/reperfusion (I/R). However the downstream gene expression programs that underlie the contribution of NF-κB to cardioprotection after late IPC are incompletely understood. The objective of this study was to delineate...

article

Gene expression profiling of blood to predict the onset of leukemia

Mario Medvedovic, Danielle Halbleib, Marian L. Miller, Kathy LaDow, more

Blood Cells, Molecules and Diseases > 2009 > 42 > 1 > 64-70

No studies have tested the hypothesis that the onset of a disease can be predicted by gene expression profiling. The AKR/J mouse strain, which spontaneously develops acute T cell lymphatic leukemia, was used to implement a novel strategy to generate global gene expression profiles of WBCs at different time points. The experimental approach was bias free because it was unknown as to which individuals...

article

In vitro multipotent differentiation and barrier function of a human mammary epithelium

Aaron M. Marshall, Vaibhav P. Pai, Maureen A. Sartor, Nelson D. Horseman

Cell and Tissue Research > 2009 > 335 > 2 > 383-395

As demonstrated by a variety of animal studies, barrier function in the mammary epithelium is essential for a fully functioning and differentiated gland. However, there is a paucity of information on barrier function in human mammary epithelium. Here, we have established characteristics of a polarizing differentiating model of human mammary epithelial cells capable of forming a high-resistance/low-conductance...

article

MicroRNAs and regeneration: Let-7 members as potential regulators of dedifferentiation in lens and inner ear hair cell regeneration of the adult newt

Panagiotis A. Tsonis, Mindy K. Call, Matthew W. Grogg, Maureen A. Sartor, more

Biochemical and Biophysical Research Communications > 2007 > 362 > 4 > 940-945

MicroRNAs are known to regulate the expression of many mRNAs by binding to complementary target sequences at the 3′UTRs. Because of such properties, miRNAs may regulate tissue-specific mRNAs as a cell undergoes transdifferentiation during regeneration. We have tested this hypothesis during lens and hair cell regeneration in newts using microarray analysis. We found that distinct sets of miRNAs are...

article

Genome-wide analyses show that nuclear and cytoplasmic RNA levels are differentially affected by dioxin

Jennifer A. Schwanekamp, Maureen A. Sartor, Saikumar Karyala, Danielle Halbleib, more

BBA - Gene Structure and Expression > 2006 > 1759 > 8-9 > 388-402

The aryl hydrocarbon receptor (AHR) mounts the body's main molecular defense against environmental toxicants by inducing a battery of genes encoding xenobiotic metabolizing proteins. The AHR is activated by polycyclic aromatic hydrocarbon toxicants, including the pervasive teratogen and carcinogen 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD or dioxin). The TCDD-activated AHR significantly changes the...

article

Developmental Characteristics of Adapting Mouse Small Intestine Crypt Cells

Christopher R. Erwin, Marcus D. Jarboe, Maureen A. Sartor, Mario Medvedovic, more

Gastroenterology > 2006 > 130 > 4 > 1324-1332

Background & Aims: Following massive small bowel resection (SBR), the remnant intestine undergoes an adaptive process characterized by increases in a number of physiologic and morphologic parameters. These changes are the result of a stimulus that increases crypt cell mitosis and augments cellular progression along the villus axis. To better define this process, we identified patterns of gene...

article

Gene expression profiles of mouse aorta and cultured vascular smooth muscle cells differ widely, yet show common responses to dioxin exposure

Alvaro Puga, Maureen A. Sartor, Ming-ya Huang, J. Kevin Kerzee, more

Cardiovascular Toxicology > 2004 > 4 > 4 > 385-403

Exposure to environmental toxicants may play a role in the onset and progression of cardiovascular disease. Many environmental agents, such as dioxin, are risk factors for atherosclerosis because they may exacerbate an underlying disease by altering gene expression patterns. Expression profiling of vascular tissues allows the simutaneous analysis of thousands of genes and may provide predictive information...

article

Critical regulation of genes for tumor cell migration by AP-1

El Mustapha Bahassi, Saikumar Karyala, Craig R. Tomlinson, Maureen A. Sartor, more

Clinical & Experimental Metastasis > 2004 > 21 > 4 > 293-304

The AP-1 transcription factor plays a critical role in regulating tumor cell proliferation and has been implicated in controlling a program of gene expression that mediates cell motility and invasion in vitro. We have utilized two dominant negative AP-1 constructs, TAM67 and aFos, each fused to GFP, to investigate the role of AP-1 complexes in an invasive, clinically derived human tumor cell line,...

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