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Sarcopenia is defined as an age associated decline in skeletal muscle mass. The pathophysiology of sarcopenia is multifactorial, with decreased caloric intake, muscle fiber denervation, intracellular oxidative stress, hormonal decline, and enhanced myostatin signaling all thought to contribute. Prevalence rates are as high as 29% and 33% in elderly community dwelling and long-term care populations,...
Reaction rate distribution measurements are reported from experiments in an SCWR-like test lattice performed with separated moderator and coolant regions. This work was done at the zero-power research reactor PROTEUS at the Paul Scherrer Institute in Switzerland. Four water-tanks were inserted into the four central moderator channels of the lattice. The derived reaction rates, captures in 238...
While X-irradiated live parasites are not an acceptable proposition for human vaccination, they offer a ready experimental system to explore mechanisms by which immunity against hookworm infection may be induced in humans. As such, we sought to further elucidate the details of this highly protective immune response induced by the irradiated vaccine in canids, with special emphasis on the cellular...
The ASP-2 protein secreted by infective larvae of the human hookworm, Necator americanus, is under development as a recombinant vaccine. Recombinant Na-ASP-2 was expressed in Pichia pastoris, and the purified protein was characterized. At the 60L scale, the 21.3kDa recombinant protein was produced at a yield of 0.4g/L. When formulated with Alhydrogel ® and injected into rats to determine immunological...
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