Search results for: Janet C. Tou

Items from 1 to 20 out of 22 results

article

Protein quality and safety evaluation of sarcoplasmic protein derived from silver carp (Hypophthalmichthys molitrix) using a rat model

Derek Warren, Lynsey Soule, Kathryn Taylor, R. Chris Skinner, more

Journal of Food Science > 85 > 8 > 2544 - 2553

Abstract Consisting of 25 to 30% of protein in carp, water‐soluble sarcoplasmic proteins lost in wash water, have been recovered and freeze‐dried into a protein‐rich powder. Study objectives were to evaluate protein quality and safety of a silver carp sarcoplasm derived protein powder (CSP) compared to commercial protein supplements, casein, and whey. In vivo protein quality assessment of CSP showed...

article

High-fructose corn syrup-55 consumption alters hepatic lipid metabolism and promotes triglyceride accumulation

Kaitlin Mock, Sundus Lateef, Vagner A. Benedito, Janet C. Tou

The Journal of Nutritional Biochemistry > 2017 > 39 > C > 32-39

High-fructose corn syrup-55 (HFCS-55) has been suggested to be more lipogenic than sucrose, which increases the risk for nonalcoholic fatty liver disease (NAFLD) and dyslipidemia. The study objectives were to determine the effects of drinking different sugar-sweetened solutions on hepatic gene expression in relation to liver fatty acid composition and risk of NAFLD. Female rats were randomly assigned...

article

Nutritional value, bioactive compounds and health benefits of lettuce (Lactuca sativa L.)

Moo Jung Kim, Youyoun Moon, Janet C. Tou, Beiquan Mou, more

Journal of Food Composition and Analysis > 2016 > 49 > C > 19-34

Lettuce is one of the most widely consumed vegetables worldwide, but its nutritional value has been underestimated. Lettuce is low in calories, fat and sodium. It is a good source of fiber, iron, folate, and vitamin C. Lettuce is also a good source of various other health-beneficial bioactive compounds. In vitro and in vivo studies have shown anti-inflammatory, cholesterol-lowering, and anti-diabetic...

article

Evaluating resveratrol as a therapeutic bone agent: preclinical evidence from rat models of osteoporosis

Janet C. Tou

Annals of the New York Academy of Sciences > 1348 > 1 > 75 - 85

Resveratrol (RSV) is a naturally occurring plant polyphenol that has potential to attenuate osteoporosis with distinct pathologies. This review evaluates preclinical evidence regarding the efficacy and safety of RSV as a therapeutic bone agent using different rat models. Limitations of these animal models are discussed, and suggestions for strengthening the experimental design of future studies are...

article

Resveratrol supplementation affects bone acquisition and osteoporosis: Pre-clinical evidence toward translational diet therapy

Janet C. Tou

BBA - Molecular Basis of Disease > 2015 > 1852 > 6 > 1186-1194

Osteoporosis is a major public health issue that is expected to rise as the global population ages. Resveratrol (RES) is a plant polyphenol with various anti-aging properties. RES treatment of bone cells results in protective effects, but dose translation from in vitro studies to clinically relevant doses is limited since bioavailability is not taken into account. The aims of this review is to evaluate...

article

Evaluating the therapeutic value of omega-3 polyunsaturated fatty acid supplementation on polycystic kidney disease and co-morbidities

Janet C Tou, Joseph C Gigliotti, Kaitlin H Maditz

Current Opinion in Food Science > 2015 > 2 > Complete > 20-28

Polycystic kidney disease (PKD) is an incurable genetic disease characterized by multiple fluid-filled renal cysts and is a leading cause of renal failure. Medical treatment options for PKD are limited. Therefore, dietary intervention offers a potentially efficacious, cost-effective, and safe therapeutic strategy for PKD. The omega-3 polyunsaturated fatty acids (n-3 PUFA) regulates multiple steps...

article

Feeding soy protein isolate and oils rich in omega-3 polyunsaturated fatty acids affected mineral balance, but not bone in a rat model of autosomal recessive polycystic kidney disease

Kaitlin H Maditz, Brenda J Smith, Matthew Miller, Chris Oldaker, more

BMC Nephrology > 2015 > 16 > 1 > 1-11

Background Polycystic kidney disease (PKD), a genetic disorder characterized by multiple cysts and renal failure at an early age. In children, kidney disease is often accompanied by disordered mineral metabolism, failure to achieve peak bone mass, and reduced adult height. Optimizing bone health during the growth stage may preserve against bone loss associated with early renal dysfunction in PKD...

article

Dietary n-3 polyunsaturated fatty acids or soy protein isolate did not attenuate disease progression in a female rat model of autosomal recessive polycystic kidney disease

Kaitlin H. Maditz, Chris Oldaker, Nainika Nanda, Vagner Benedito, more

Nutrition Research > 2014 > 34 > 6 > 526-534

Polycystic kidney disease (PKD) is an incurable genetic disorder that is characterized by multiple benign cysts. As PKD advances, cyst growth increases kidney volume, decreases renal function, and may lead to end-stage renal disease; however, in a PKD rat model, feeding soy protein isolate (SPI) reduced cyst proliferation and growth. The n-3 polyunsaturated fatty acids (PUFAs) are noted for their...

article

The past, present, and future of National Aeronautics and Space Administration spaceflight diet in support of microgravity rodent experiments

Gwo-Shing Sun, Janet C. Tou, Diane Yu, Beverly E. Girten, more

Nutrition > 2014 > 30 > 2 > 125-130

Rodents have been the most frequently flown animal model used to study physiological responses to the space environment. In support of future of space exploration, the National Aeronautics and Space Administration (NASA) envisions an animal research program focused on rodents. Therefore, the development of a rodent diet that is suitable for the spaceflight environment including long duration spaceflight...

article

Resveratrol supplementation preserves long bone mass, microstructure, and strength in hindlimb-suspended old male rats

Stephanie M. Durbin, Janna R. Jackson, Michael J. Ryan, Joseph C. Gigliotti, more

Journal of Bone and Mineral Metabolism > 2014 > 32 > 1 > 38-47

Resveratrol has gained popularity as an “anti-aging” compound due to its antioxidant and anti-inflammatory properties. Few studies have investigated the role of resveratrol supplementation in the prevention of age-related bone loss and skeletal disuse despite increased inactivity and age-related bone loss in the elderly. The objective of the study was to investigate the effect of resveratrol supplementation...

article

Evidence for a role of proteins, lipids, and phytochemicals in the prevention of polycystic kidney disease progression and severity

Kaitlin H Maditz, Joseph C Gigliotti, Janet C Tou

Nutrition Reviews > 71 > 12 > 802 - 814

Polycystic kidney disease (PKD) is a heritable disease characterized by renal cysts and is a leading cause of end‐stage renal disease. Dietary intervention offers a potentially efficacious, cost‐effective, and safe therapeutic option for PKD. The aim of this article was to review studies investigating the effect of dietary components on PKD and potential mechanisms of action. Low‐protein diets are...

article

Characterization of lipids and antioxidant capacity of novel nutraceutical egg products developed with omega‐3‐rich oils

Nissan M Kassis, Joseph C Gigliotti, Sarah K Beamer, Janet C Tou, more

Journal of the Science of Food and Agriculture > 92 > 1 > 66 - 73

BACKGROUND: Cardiovascular disease has had an unquestioned status of the number one cause of death in the US since 1921. Omega‐3 polyunsaturated fatty acids (ω‐3 PUFAs) have cardio‐protective benefits. However, egg is typically a poor source of ω‐3 PUFAs and, in general, the American diet is low in these cardio‐protective fatty acids. Novel, nutritionally enhanced egg products were developed by substituting...

article

Chemical properties of surimi seafood nutrified with ω-3 rich oils

Brittney N. Pietrowski, Reza Tahergorabi, Kristen E. Matak, Janet C. Tou, more

Food Chemistry > 2011 > 129 > 3 > 912-919

Surimi-based seafood products are widely accepted and enjoyed worldwide. The US consumption increased in 1980s; however, it leveled thereafter. Food products nutrified with ω-3 polyunsaturated fatty acids (PUFAs) are in increasing demand due to demonstrated health benefits. Currently, surimi seafood is not nutrified with ω-3 PUFAs. In the present study, surimi seafood was nutritionally-enhanced with...

article

Consumption of different sources of omega-3 polyunsaturated fatty acids by growing female rats affects long bone mass and microarchitecture

Robin Lukas, Joseph C. Gigliotti, Brenda J. Smith, Stephanie Altman, more

Bone > 2011 > 49 > 3 > 455-462

Omega-3 polyunsaturated fatty acids (ω-3 PUFAs) consumption has been reported to improve bone health. However, sources of ω-3 PUFAs differ in the type of fatty acids and structural form. The study objective was to determine the effect of various ω-3 PUFAs sources on bone during growth. Young (age 28d) female Sprague–Dawley rats were randomly assigned (n=10/group) to a high fat 12% (wt) diet consisting...

article

Extraction and characterisation of lipids from Antarctic krill (Euphausia superba)

Joseph C. Gigliotti, Matthew P. Davenport, Sarah K. Beamer, Janet C. Tou, more

Food Chemistry > 2011 > 125 > 3 > 1028-1036

There is significant commercial interest in oil extraction from krill because it is rich in omega-3 polyunsaturated fatty acids (n-3 PUFA) such as eicosapentaenoic (EPA, 20:5n3) and docosahexaenoic (DHA, 22:6n3) acids. The objectives were to determine oil extraction efficiency using different solvent systems and the composition of extracted oil and spent krill following extraction. Extraction efficiency...

article

Consumption of krill protein concentrate prevents early renal injury and nephrocalcinosis in female Sprague–Dawley rats

Joseph C. Gigliotti, Amber L. Smith, Jacek Jaczynski, Janet C. Tou

Urological Research > 2011 > 39 > 1 > 59-67

Female Sprague–Dawley rats provide an animal model for studying the role of nutrition in renal health due to their sensitivity to diet-induced alterations in kidney function. Nephrocalcinosis, a common renal abnormality found in rats, has been implicated in subsequent renal failure. Simple dietary manipulations, such as changing the source of dietary protein, may influence nephrocalcinosis. This study...

article

Evaluation of the nutrient-upgraded rodent food bar for rodent spaceflight experiments

Gwo-Shing Sun, Janet C. Tou, Kurt Liittschwager, Anna M. Herrera, more

Nutrition > 2010 > 26 > 11-12 > 1163-1169

Selection of an appropriate diet for rodent spaceflight experiments is critical and may have significant effects on mission results. The National Aeronautics and Space Administration (NASA) rodent food bar (RFB) was reformulated and designated as the nutrient-upgraded RFB (NuRFB). The objectives of this study were to determine whether the NuRFB nutrient formulation meets the 1995 National Research...

article

Nutritional composition of novel nutraceutical egg products developed with omega-3-rich oils

Nissan M. Kassis, Sarah K. Beamer, Kristen E. Matak, Janet C. Tou, more

LWT - Food Science and Technology > 2010 > 43 > 8 > 1204-1212

The ω-3 fatty acids (ω-3 FAs)-fortified eggs are typically developed through alteration of hen feed. The present study aimed at creating ω-3 FAs-fortified egg products via processing. Novel, nutritionally-enhanced egg products were developed by substituting cholesterol-containing yolk with ω-3 FAs-rich flaxseed, menhaden, algae, or krill oil. Experimental egg products (egg whites, ω-3 oils, and annatto),...

article

Determination of Digestibility, Tissue Deposition, and Metabolism of the Omega-3 Fatty Acid Content of Krill Protein Concentrate in Growing Rats

Kayla M. Bridges, Joseph C. Gigliotti, Stephanie Altman, Jacek Jaczynski, more

Journal of Agricultural and Food Chemistry > 2010 > 58 > 5 > 2830 - 2837

article

Prenatal cadmium exposure dysregulates sonic hedgehog and Wnt/β-catenin signaling in the thymus resulting in altered thymocyte development

Miranda L. Hanson, Kathleen M. Brundage, Rosana Schafer, Janet C. Tou, more

Toxicology and Applied Pharmacology > 2010 > 242 > 2 > 136-145

Cadmium (Cd) is both an environmental pollutant and a component of cigarette smoke. Although evidence demonstrates that adult exposure to Cd causes changes in the immune system, there are limited reports in the literature of immunomodulatory effects of prenatal exposure to Cd. The sonic hedgehog (Shh) and Wnt/β-catenin pathways are required for thymocyte maturation. Several studies have demonstrated...

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Search results for: Janet C. Tou

Protein quality and safety evaluation of sarcoplasmic protein derived from silver carp (Hypophthalmichthys molitrix) using a rat model

High-fructose corn syrup-55 consumption alters hepatic lipid metabolism and promotes triglyceride accumulation

Nutritional value, bioactive compounds and health benefits of lettuce (Lactuca sativa L.)

Evaluating resveratrol as a therapeutic bone agent: preclinical evidence from rat models of osteoporosis

Resveratrol supplementation affects bone acquisition and osteoporosis: Pre-clinical evidence toward translational diet therapy

Evaluating the therapeutic value of omega-3 polyunsaturated fatty acid supplementation on polycystic kidney disease and co-morbidities

Feeding soy protein isolate and oils rich in omega-3 polyunsaturated fatty acids affected mineral balance, but not bone in a rat model of autosomal recessive polycystic kidney disease

Dietary n-3 polyunsaturated fatty acids or soy protein isolate did not attenuate disease progression in a female rat model of autosomal recessive polycystic kidney disease

The past, present, and future of National Aeronautics and Space Administration spaceflight diet in support of microgravity rodent experiments

Resveratrol supplementation preserves long bone mass, microstructure, and strength in hindlimb-suspended old male rats

Evidence for a role of proteins, lipids, and phytochemicals in the prevention of polycystic kidney disease progression and severity

Characterization of lipids and antioxidant capacity of novel nutraceutical egg products developed with omega‐3‐rich oils

Chemical properties of surimi seafood nutrified with ω-3 rich oils

Consumption of different sources of omega-3 polyunsaturated fatty acids by growing female rats affects long bone mass and microarchitecture

Extraction and characterisation of lipids from Antarctic krill (Euphausia superba)

Consumption of krill protein concentrate prevents early renal injury and nephrocalcinosis in female Sprague–Dawley rats

Evaluation of the nutrient-upgraded rodent food bar for rodent spaceflight experiments

Nutritional composition of novel nutraceutical egg products developed with omega-3-rich oils

Determination of Digestibility, Tissue Deposition, and Metabolism of the Omega-3 Fatty Acid Content of Krill Protein Concentrate in Growing Rats

Prenatal cadmium exposure dysregulates sonic hedgehog and Wnt/β-catenin signaling in the thymus resulting in altered thymocyte development

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