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Les effets indésirables liés aux médicaments causeraient 10 000 décès par an en France. Le plus souvent, la détection de ces effets repose sur les déclarations et l’écriture de règles d’alerte et de prévention est faite à dire d’expert lors de revues des dossiers. De plus, les spécificités des services ne sont pas prises en compte (patients, pratiques, connaissances). L’objectif du projet européen...
The aim of this study was to evaluate the interest of a new three-dimensional epithelial model cultivated from human corneal cells to replace animal testing in the assessment of eye tolerance. To this end, 65 formulated cosmetic products and 36 chemicals were tested by means of this in vitro model using a simplified toxicokinetic approach. The chemicals were selected from the ECETOC data bank and...
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