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A replication-deficient recombinant adenovirus (Ad5-LFA-3/IgG1) that encodes secreted LFA-3/IgG1 was constructed for gene therapy treatment of psoriasis. The purpose of this study was to develop a real-time PCR method for pharmacokinetic and biodistribution studies of Ad5-LFA-3/IgG1 within the circulation and organs. This method showed good specificity, sensitivity and reproducibility over a wide...
Naphthoquine phosphate and artemisinine are two antimalarials developed in China. Both drugs have proven to be efficacious and well tolerated as monotherapy as well as in combination in patients suffering from malaria. The Co-naphthoquine, a novel antimalarial combination, is an oral fixed combination tablet of the naphthoquine phosphate and artemisinine. Artemisinin is characterised by a rapid onset...
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