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Killer‐cell immunoglobulin‐like receptors (KIR) control natural killer (NK) cell functions by recognizing HLA molecules and modulating the activity of NK cells. The KIR gene cluster contains polymorphic and highly homologous genes. Diversity of the KIR region is achieved through differences in gene content, allelic polymorphism, and gene copy number, which result in unrelated individuals having different...
The range of HLA typing for successful hematopoietic stem cell transplantation (HSCT) is gradually expanding with the next‐generation sequencing (NGS)‐based improvement in its quality. However, it is influenced by the allocation of finances and laboratory conditions. HLA‐A, ‐B, ‐C, ‐DRB1/3/4/5, ‐DQA1, ‐DQB1, ‐DPA1, and ‐DPB1 alleles were genotyped at the 3‐field level by amplicon‐based NGS using MiSeqDx...
HLA genes play a pivotal role for successful hematopoietic stem cell transplantation (HSCT). There is an increasing need for sophisticated screening of donor HLA genotypes for unrelated HSCT. Next generation sequencing (NGS) has emerged as an alternative for classical Sanger sequence for HLA typing. In this study, HLA‐A, ‐B, and ‐DRB1 alleles were genotyped at the allelic (6‐digit) level using MiSeqDx...
Some HLA alleles have been shown to be associated with susceptibility to cytomegalovirus (CMV) disease incidence in vitro. The objective of this study was to identify correlations between donor HLA allotypes and CMV disease incidence in patients with acute myeloid leukemia who had undergone allogeneic hematopoietic stem cell transplantation (HSCT). Methods and materials we retrospectively analyzed...
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