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TRPP2 channel protein belongs to the superfamily of transient receptor potential (TRP) channels and is widely expressed in various tissues, including smooth muscle in digestive gut. Accumulating evidence has demonstrated that TRPP2 can mediate Ca2+ release from Ca2+ stores. However, the functional role of TRPP2 in gallbladder smooth muscle contraction still remains unclear. In this study, we used...
Phospholipase A 2 (PLA 2 ) is an important component in snake venoms. Here, an acidic PLA 2 , designated PA2-Vb was isolated from the Trimeresurus stejnegeri snake venom. PA2-Vb acts on a protease-activated receptor (PAR-1) to evoke Ca 2+ release through the inositol 1,4,5-trisphosphate receptor (IP 3 R) and induces mouse aorta contraction. PAR-1, phospholipase...
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