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Cytokine detection is an essential topic for biomedical research. Herein we demonstrated an ex-vivo device based on a silica optical fibre for monitoring of locally variable cytokine IL-6 concentrations using a sandwich immunoassay scheme. The fibre was designed to be introduced into the perforated catheter with micrometre size holes drilled along its length to enable fluid exchange between the outside...
In vivo studies on disc mechanics show loss of fluid from the intervertebral disc (IVD) during loading and full recovery during rest. Previous work indicated that in vitro recovery is hampered after static loading. The aim of the present study was to investigate the role of the endplate after dynamic and static loading on mechanical recovery in vitro.Lumbar spines (caprine) were obtained from the...
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