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We hypothesized that improved survival of internal mammary artery (IMA) conduits compared to saphenous vein grafts (SVG) may be due to preserved endothelial nitric oxide (NO) activity in arterial grafts. For this purpose, we studied endothelium-dependent and -independent dilator and constrictor functions in IMA (N = 6), SVG (N = 25), and native atherosclerotic vessels (NAV) (N = 30) in 30 patients...
Although dobutamine (D) is routinely used as a surrogate for exercise, there is often discordance between exercise and D stress tests, especially in pts with mild coronary artery disease (CAD). While physical exercise causes myocardial ischemia by a combination of increase in demand and epicardial coronary (EC) constriction, it is not known whether constriction plays a role in D-induced ischemia...