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The placenta is important in providing a healthy environment for the fetus and plays a central role in the pathophysiology of pre-eclampsia (PE). The circadian rhythm is implicated in fetal and placental growth and development. We hypothesize that derangements in prenatal epigenetic programming of circadian clock-related genes in placental and newborn tissues are associated with disease severity of...
Preeclampsia (PE), foetal growth restriction (FGR) and preterm birth (PTB) are associated with an increased risk on the development of cardiovascular disease in offspring. Abnormal programming of the embryonic and extra-embryonic vasculature may be involved. The umbilical cord could be a good model for studying foetal vascular development.We examined the morphology of the umbilical cord vasculature...