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The focus of this study was to analyze polymorphisms in the HLA gene at 11 loci in 4845 Chinese Han populations using next‐generation sequencing methods, and to compare common and well‐documented (CWD) allelic differences between China and other CWD lists. A total of 44 DPB1 alleles, 13 DPA1 alleles, 20 DQA1 alleles and 19 DRB3/4/5 alleles were detected in this study. About 20%–50% of the CWD alleles...
We collected HLA typing data from 653 families in the Eastern Han Chinese population. HLA‐A, B, C, DRB1, DRB3, DRB4, DRB5, DQA1, DQB1, DPA1, and DPB1 (HLA‐11 loci) typing of 1781 subjects was performed using a commercial next‐generation sequencing (NGS) method in our laboratory. The phasing of haplotypes in each family was determined by Mendelian segregation. Haplotype analysis revealed 1634 different...
Mastering the SNP content in the HLA region can be based on it to judiciously select unrelated donor stem cells with preferable MHC matching to lower postoperative complications. Herein, quantitative PCR‐based primers and probes were designed for 10 transplants outcome‐associated SNP loci with two‐allelic polymorphism, and then a new detection system (“HLA‐10‐SNP”) was established. Compared with Sanger...
With the goal of improving the population‐specific criteria to distinguish KIR genotypes and haplotypes in the region, we examined the KIR gene and haplotype data of Eastern Han based on a large population and analyzed the component genes of centromeric (Cen) and telomeric (Tel) KIR haplotype segments, which may differ in the protection they provide in hematopoietic stem cell transplantation. Samples...
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