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The breast cancer susceptibility protein BRCA2 is essential for recombinational DNA repair. BRCA2 specifically binds to RAD51 via eight BRC repeat motifs and delivers RAD51 to double-stranded DNA breaks. In this study, a mammalian two-hybrid assay and competitive ELISA showed that the interaction between BRC repeat 4 (BRC4) and RAD51 was strengthened by the substitution of a single BRC4 amino acid...
IκB inhibits nuclear factor kappa B (NF-κB), which is known to regulate the expression of various genes, including genes involved in inflammation. Recently, a novel IκB family protein, ‘molecule possessing ankyrin repeats induced by lipopolysaccharide’ (MAIL), was identified. MAIL is a nuclear-acting, inducible protein, unlike typical IκB proteins. However, the mechanism of its induction by lipopolysaccharide...
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