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Cyclic ADP-ribose (cADPR) induces the release of Ca 2+ from microsomes of pancreatic islets for insulin secretion. It has been demonstrated that cADPR binds to FK506-binding protein 12.6 (FKBP 12.6) on rat islet ryanodine receptor and that the binding of cADPR to FKBP12.6 frees the ryanodine receptor from FKBP12.6, causing it to release Ca 2+ [Noguchi, N., Takasawa, S., Nata, K., Tohgo,...
Reg (regenerating gene), first isolated from a rat regenerating islet cDNA library, is expressed in regenerating islet β-cells. Recently, it has been revealed that Reg and Reg-related genes constitute a multigene family, Reg family, which consists of three subtypes (type I, II, III) based on the primary structures of the encoded proteins of the genes. In mouse, type I and type II Reg genes (i.e. RegI...
Protein phosphatase 2C (PP2C) is one of four major classes of protein serine/threonine phosphatase and is considered to have a role in signal transduction of stress responses. It has two isotypes, α and β, encoded by different genes. In this study, the mouse PP2Cβ gene was mapped byin situhybridization to chromosome 17E 4–5.
Reg, first isolated from a rat regenerating islet cDNA library, is expressed in regenerating islet β-cells. Recently, it has been revealed that Reg and Reg-related genes constitute a multigene family, the Reg family. In human, the four REG family genes, i.e., REG Iα, REG Iβ, REG-related sequence (RS) and HIPIPAP, have so far been isolated. In this study, we analyzed YAC clones containing the four...
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