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BACKGROUND & AIMS: Peristaltic contraction of the esophagus and relaxation of the lower esophageal sphincter (LES) are mediated by nitric oxide (NO.)-producing myenteric nerves. NO synthase immunoreactivity and calcitonin gene-related peptide (CGRP) immunoreactivity colocalize in these nerves. CGRP relaxes the LES and decreases the amplitude of esophageal peristalsis. The aim of this study was...
Calcium release from intracellular stores plays a central role in excitation–contraction coupling of striated and smooth muscle cells. Two main intracellular calcium pools have been identified in phasic smooth muscle: (1) the inositol 1,4,5-trisphosphate-sensitive and the (2) ryanodine-sensitive calcium stores. We studied the contribution of the ryanodine-sensitive calcium stores to the excitation–contraction...
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