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Mutations in SOD1 cause 13% of familial amyotrophic lateral sclerosis. In the SOD1 Gly93Ala rat model of amyotrophic lateral sclerosis, the antisense oligonucleotide ISIS 333611 delivered to CSF decreased SOD1 mRNA and protein concentrations in spinal cord tissue and prolonged survival. We aimed to assess the safety, tolerability, and pharmacokinetics of ISIS 333611 after intrathecal administration...
We used five Drosophila melanogaster recurrent F1s to investigate genotypic differences in space use and movement patterns, focusing on the behaviour of teneral females and individually marked young adults that were allowed free access to large, structurally complex environments. Teneral females from the five F1s differed in their propensity to hide after emergence and in the height at which they...
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