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Model placebo multiple unit oral dosage forms were prepared by the processes of extrusion and spheronisation. The non-invasive technique of gamma scintigraphy was used to monitor the gastrointestinal transit of these radiolabelled dosage forms. Standard sized units (1.18-1.40 mm) of density 2.0 and 2.4 g cm -3 were compared with similarly sized control units of 1.5 g cm -3...
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