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In July, 1999, a single dose of live-attenuated SA 14-14-2 Japanese encephalitis vaccine was given to children aged 1–15 years in the Terai region of Nepal. Cases of natural infection occurred almost immediately. Our aim was to assess the long-term protective effect of this vaccination. In 2000, this same population had a second seasonal exposure to the virus. We therefore did a case-control study...
In China, since 1989, an estimated 120 million children have been immunised with the SA 14–14–2 live-attenuated Japanese encephalitis (JE) vaccine at ages 1, 2, and 6 years. A case-control study of licensed vaccine found two doses to be 98% effective. Subsequently, researchers found that single-dose vaccine efficacy was high; we aimed to confirm this result.During July 11–24, 1999, 160000 doses of...