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The major metabolite of duloxetine is a glucuronide conjugate of 4‐hydroxy duloxetine (4‐HD). However, interestingly, there have been no reports determining concentrations of 4‐HD and no fully validated method has been established for measuring duloxetine and 4‐HD in rat plasma. We developed a method for the simultaneous quantification of duloxetine and its metabolite in rat plasma using high‐performance...
The anti-diarrheal and spasmolytic activities of Soonkijangquebo(TM) (SKJQB), a Korean herbal anti-diarrheal formulation, were subjected to pharmacological evaluation. SKJQB, at a dose of 50-200mg/kg, inhibited castor oil-induced diarrhea in mice. The median effective dose (ED 50 ) for the anti-diarrheal effect was 93mg/kg. In isolated rabbit jejunum preparations, SKJQB produced a spasmolytic...
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