Search results for: Catharina Svanborg

Items from 1 to 20 out of 36 results

article

Long‐term prevention of bladder cancer progression by alpha1‐oleate alone or in combination with chemotherapy

Tran Thi Hien, Ines Ambite, Murphy Lam Yim Wan, Michele Cavalera, more

International Journal of Cancer > 153 > 3 > 584 - 599

Bladder cancer is common and one of the most costly cancer forms, due to a lack of curative therapies. Recently, clinical safety and efficacy of the alpha1‐oleate complex was demonstrated in a placebo‐controlled study of nonmuscle invasive bladder cancer. Our study investigated if long‐term therapeutic efficacy is improved by repeated treatment cycles and by combining alpha1‐oleate with low‐dose chemotherapy...

article

Lipid bilayer composition as a determinant of cancer cell sensitivity to tumoricidal protein‐lipid complexes

James C. S. Ho, Sartaj Ahmad Mir, Michele Cavalera, Parisa Esmaeili, more

BioFactors > 48 > 5 > 1145 - 1159

Complexes formed by the alpha1 N‐terminal peptide of alpha‐lactalbumin and oleic acid (alpha1‐oleate) interact with lipid bilayers. Plasma membrane perturbations trigger tumor cell death but normal differentiated cells are more resistant, and their plasma membranes are less strongly affected. This study examined membrane lipid composition as a determinant of tumor cell reactivity. Bladder cancer tissue...

article

Bladder cancer therapy without toxicity—A dose‐escalation study of alpha1‐oleate

Tran Thi Hien, Ines Ambite, Daniel Butler, Murphy Lam Yim Wan, more

International Journal of Cancer > 147 > 9 > 2479 - 2492

Potent chemotherapeutic agents are required to counteract the aggressive behavior of cancer cells and patients often experience severe side effects, due to tissue toxicity. Our study addresses if a better balance between efficacy and toxicity can be attained using the tumoricidal complex alpha1‐oleate, formed by a synthetic, alpha‐helical peptide comprising the N‐terminal 39 amino acids of alpha‐lactalbumin...

article

HAMLET – A protein-lipid complex with broad tumoricidal activity

James C.S. Ho, Aftab Nadeem, Catharina Svanborg

Biochemical and Biophysical Research Communications > 2017 > 482 > 3 > 454-458

HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells) is a tumoricidal protein-lipid complex with broad effects against cancer cells of different origin. The therapeutic potential is emphasized by a high degree of specificity for tumor tissue. Here we review early studies of HAMLET, in collaboration with the Orrenius laboratory, and some key features of the subsequent development of the HAMLET...

chapter

Hamlet; A Novel Tool to Identify Apoptotic Pathways in Tumor Cells

Caroline Düringer, Oskar Hallgren, Lotta Gustafsson, Jenny Petterson, more

Application of Apoptosis to Cancer Treatment > 223-245

Tumor cells often carry mutations in genes that control cell survival, and become resistant to signals that trigger cell death. Yet, some cell death pathways remain intact in tumor cells. If identified, these pathways might be exploited to selectively remove tumor cells. HAMLET (human α-lactalbumin made lethal to tumor cells) is a protein-lipid complex derived from human milk that activates cell death...

article

The Molecular Motor F-ATP Synthase Is Targeted by the Tumoricidal Protein HAMLET

James Ho, Hendrik Sielaff, Aftab Nadeem, Catharina Svanborg, more

Journal of Molecular Biology > 2015 > 427 > 10 > 1866-1874

HAMLET (human alpha-lactalbumin made lethal to tumor cells) interacts with multiple tumor cell compartments, affecting cell morphology, metabolism, proteasome function, chromatin structure and viability. This study investigated if these diverse effects of HAMLET might be caused, in part, by a direct effect on the ATP synthase and a resulting reduction in cellular ATP levels. A dose-dependent reduction...

article

The Humoral Pattern Recognition Molecule PTX3 Is a Key Component of Innate Immunity against Urinary Tract Infection

Sébastien Jaillon, Federica Moalli, Bryndis Ragnarsdottir, Eduardo Bonavita, more

Immunity > 2014 > 40 > 4 > 621-632

Immunity in the urinary tract has distinct and poorly understood pathophysiological characteristics and urinary tract infections (UTIs) are important causes of morbidity and mortality. We investigated the role of the soluble pattern recognition molecule pentraxin 3 (PTX3), a key component of the humoral arm of innate immunity, in UTIs. PTX3-deficient mice showed defective control of UTIs and exacerbated...

article

Rare Emergence of Symptoms during Long-Term Asymptomatic Escherichia coli 83972 Carriage without an Altered Virulence Factor Repertoire

Béla Köves, Ellaine Salvador, Jenny Grönberg-Hernández, Jaroslaw Zdziarski, more

The Journal of Urology > 2014 > 191 > 2 > 519-528

Asymptomatic bacteriuria established by intravesical inoculation of Escherichia coli 83972 is protective in patients with recurrent urinary tract infections. In this randomized, controlled crossover study a total of 3 symptomatic urinary tract infection episodes developed in 2 patients while they carried E. coli 83972. We examined whether virulence reacquisition by symptom isolates may account for...

article

Electrostatic interactions play an essential role in the binding of oleic acid with α‐lactalbumin in the HAMLET‐like complex: A study using charge‐specific chemical modifications

Yongjing Xie, Soyoung Min, Níal P. Harte, Hannah Kirk, more

Proteins: Structure, Function, and Bioinformatics > 81 > 1 > 1 - 17

Human α‐lactalbumin made lethal to tumor cells (HAMLET) and its analogs are partially unfolded protein‐oleic acid (OA) complexes that exhibit selective tumoricidal activity normally absent in the native protein itself. To understand the nature of the interaction between protein and OA moieties, charge‐specific chemical modifications of lysine side chains involving citraconylation, acetylation, and...

article

HAMLET Forms Annular Oligomers When Deposited with Phospholipid Monolayers

Anne Baumann, Anja Underhaug Gjerde, Ming Ying, Catharina Svanborg, more

Journal of Molecular Biology > 2012 > 418 > 1-2 > 90-102

Recently, the anticancer activity of human α-lactalbumin made lethal to tumor cells (HAMLET) has been linked to its increased membrane affinity in vitro, at neutral pH, and ability to cause leakage relative to the inactive native bovine α-lactalbumin (BLA) protein. In this study, atomic force microscopy resolved membrane distortions and annular oligomers (AOs) produced by HAMLET when deposited at...

article

Do Escherichia coli strains causing acute cystitis have a distinct virulence repertoire?

Birgit Stattin Norinder, Béla Köves, Manisha Yadav, Annelie Brauner, more

Microbial Pathogenesis > 2012 > 52 > 1 > 10-16

Bacterial virulence factors influence the site and severity of urinary tract infections. While pyelonephritis-associated molecular traits have been defined, virulence factors specific for acute cystitis strains have not been identified. This study examined the virulence factor repertoire of 247 Escherichia coli strains, prospectively isolated from women with community-acquired acute cystitis. Fim...

article

Susceptibility to acute pyelonephritis or asymptomatic bacteriuria: Host–pathogen interaction in urinary tract infections

Bryndís Ragnarsdóttir, Catharina Svanborg

Pediatric Nephrology > 2012 > 27 > 11 > 2017-2029

Our knowledge of the molecular mechanisms of urinary tract infection (UTI) pathogenesis has advanced greatly in recent years. In this review, we provide a general background of UTI pathogenesis, followed by an update on the mechanisms of UTI susceptibility, with a particular focus on genetic variation affecting innate immunity. The innate immune response of the host is critically important in the...

article

Structure and function of human α‐lactalbumin made lethal to tumor cells (HAMLET)‐type complexes

Ann‐Kristin Mossberg, Kenneth Hun Mok, Ludmilla A. Morozova‐Roche, Catharina Svanborg

The FEBS Journal > 277 > 22 > 4614 - 4625

Human α‐lactalbumin made lethal to tumor cells (HAMLET) and equine lysozyme with oleic acid (ELOA) are complexes consisting of protein and fatty acid that exhibit cytotoxic activities, drastically differing from the activity of their respective proteinaceous compounds. Since the discovery of HAMLET in the 1990s, a wealth of information has been accumulated, illuminating the structural, functional...

article

HAMLET Treatment Delays Bladder Cancer Development

Ann-Kristin Mossberg, Yuchuan Hou, Majlis Svensson, Bo Holmqvist, more

The Journal of Urology > 2010 > 183 > 4 > 1590-1597

HAMLET is a protein-lipid complex that kills different types of cancer cells. Recently we observed a rapid reduction in human bladder cancer size after intravesical HAMLET treatment. In this study we evaluated the therapeutic effect of HAMLET in the mouse MB49 bladder carcinoma model.Bladder tumors were established by intravesical injection of MB49 cells into poly L-lysine treated bladders of C57BL/6...

article

α-Lactalbumin, Engineered to be Non-Native and Inactive, Kills Tumor Cells When in Complex with Oleic Acid: A New Biological Function Resulting from Partial Unfolding

Jenny Pettersson-Kastberg, Ann-Kristin Mossberg, Maria Trulsson, Yeon Joong Yong, more

Biophysical Journal > 2010 > 98 > 3 Supplement 1 > 629a

article

α-Lactalbumin, Engineered to be Nonnative and Inactive, Kills Tumor Cells when in Complex with Oleic Acid: A New Biological Function Resulting from Partial Unfolding

Jenny Pettersson-Kastberg, Ann-Kristin Mossberg, Maria Trulsson, Yeon Joong Yong, more

Journal of Molecular Biology > 2009 > 394 > 5 > 994-1010

HAMLET (human alpha-lactalbumin made lethal to tumor cells) is a tumoricidal complex consisting of partially unfolded protein and fatty acid and was first identified in casein fractions of human breast milk. The complex can be produced from its pure components through a modified chromatographic procedure where preapplied oleic acid binds with partially unfolded α-lactalbumin on the stationary phase...

article

Virulence properties of asymptomatic bacteriuria Escherichia coli

Amanda N. Mabbett, Glen C. Ulett, Rebecca E. Watts, Jai J. Tree, more

International Journal of Medical Microbiology > 2009 > 299 > 1 > 53-63

In asymptomatic bacteriuria (ABU), bacteria colonize the urinary tract without provoking symptoms. Here, we compared the virulence properties of a collection of ABU Escherichia coli strains to cystitis and pyelonephritis strains. Specific urinary tract infection (UTI)-associated virulence genes, hemagglutination characteristics, siderophore production, hemolysis, biofilm formation, and the ability...

article

Shiga Toxin-Mediated Disease in MyD88-Deficient Mice Infected with Escherichia coli O157:H7

Carla Calderon Toledo, Trisha Jayne Rogers, Majlis Svensson, Ramesh Tati, more

The American Journal of Pathology > 2008 > 173 > 5 > 1428-1439

Toll-like receptors (TLRs) are key factors of innate immunity that detect pathogen invasion and trigger a host response. TLR4 can mediate a response through adaptor molecules, MyD88 or TRIF. In the present study, streptomycin-treated MyD88 ^−/− , Tlr4 ^−/− , Trif ^Lps2/Lps2 , and C57BL/6 wild-type (WT) mice were infected with either Shiga toxin (Stx)-producing or non-producing...

article

Pathogenomics: An updated European Research Agenda

Andreas Demuth, Yair Aharonowitz, Till T. Bachmann, Gabriele Blum-Oehler, more

Infection, Genetics and Evolution > 2008 > 8 > 3 > 386-393

The emerging genomic technologies and bioinformatics provide novel opportunities for studying life-threatening human pathogens and to develop new applications for the improvement of human and animal health and the prevention, treatment, and diagnosis of infections. Based on the ecology and population biology of pathogens and related organisms and their connection to epidemiology, more accurate typing...

article

HAMLET, protein folding, and tumor cell death

K. Hun Mok, Jenny Pettersson, Sten Orrenius, Catharina Svanborg

Biochemical and Biophysical Research Communications > 2007 > 354 > 1 > 1-7

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INFONA - science communication portal

Search results for: Catharina Svanborg

Long‐term prevention of bladder cancer progression by alpha1‐oleate alone or in combination with chemotherapy

Lipid bilayer composition as a determinant of cancer cell sensitivity to tumoricidal protein‐lipid complexes

Bladder cancer therapy without toxicity—A dose‐escalation study of alpha1‐oleate

HAMLET – A protein-lipid complex with broad tumoricidal activity

Hamlet; A Novel Tool to Identify Apoptotic Pathways in Tumor Cells

The Molecular Motor F-ATP Synthase Is Targeted by the Tumoricidal Protein HAMLET

The Humoral Pattern Recognition Molecule PTX3 Is a Key Component of Innate Immunity against Urinary Tract Infection

Rare Emergence of Symptoms during Long-Term Asymptomatic Escherichia coli 83972 Carriage without an Altered Virulence Factor Repertoire

Electrostatic interactions play an essential role in the binding of oleic acid with α‐lactalbumin in the HAMLET‐like complex: A study using charge‐specific chemical modifications

HAMLET Forms Annular Oligomers When Deposited with Phospholipid Monolayers

Do Escherichia coli strains causing acute cystitis have a distinct virulence repertoire?

Susceptibility to acute pyelonephritis or asymptomatic bacteriuria: Host–pathogen interaction in urinary tract infections

Structure and function of human α‐lactalbumin made lethal to tumor cells (HAMLET)‐type complexes

HAMLET Treatment Delays Bladder Cancer Development

α-Lactalbumin, Engineered to be Non-Native and Inactive, Kills Tumor Cells When in Complex with Oleic Acid: A New Biological Function Resulting from Partial Unfolding

α-Lactalbumin, Engineered to be Nonnative and Inactive, Kills Tumor Cells when in Complex with Oleic Acid: A New Biological Function Resulting from Partial Unfolding

Virulence properties of asymptomatic bacteriuria Escherichia coli

Shiga Toxin-Mediated Disease in MyD88-Deficient Mice Infected with Escherichia coli O157:H7

Pathogenomics: An updated European Research Agenda

HAMLET, protein folding, and tumor cell death

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