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The possible adjuvant effect of diesel exhaust particles (DEP) on the response to the model allergen ovalbumin (OA) was studied in BALB/c mice using the popliteal lymph node (PLN) assay. In addition to changes in PLN weight, cell numbers and cell proliferation, specific serum IgE anti-OA antibody levels were measured. OA inoculated together with DEP into one hind footpad gave a significantly augmented...
The mouse (BALB/c) popliteal lymph node assay (PLNA) was used to study the possible adjuvant effect of diesel exhaust particles (DEP), carbon black (CB) and Al(OH) 3 on the immune response to the model allergen ovalbumin (OA). Three different lymph node parameters were determined as a measure of the local inflammatory response: increase in weight, increase in cell numbers, and increase in...
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