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Introduction: Interleukin-11 (IL-11) is a pleiotropic cytokine with wide biological activities in bone and hematologic compartments. Its activity is mediated by binding to a multisubunit complex formed by the IL-11-specific receptor α-chain (IL-11Rα) and the signal-transducing receptor β-chain (gp130). Controlled expression of IL-11Rα is therefore a key element regulating IL-11 binding and responsiveness...
Introduction: The recently discovered cytokine interleukin (IL)-15 shares several biological activities with IL-2 and both cytokines use IL-2 receptor β and γ for binding, and signaling. Furthermore an IL-15 specific receptor chain (IL-15Rα) has been described which is structurally related to IL-2Rα chain by the presence of a sushi domain involved in cytokine binding. This domain is encoded...
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