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In 2006, the New England Journal of Medicine selected medical imaging as one of the eleven most important innovations of the past 1,000 years, primarily due to its ability to allow physicians and researchers to visualize the very nature of disease. As a result of the broad-based adoption of micro imaging technologies, preclinical researchers today are generating terabytes of image data from both anatomic...
Amyloidosis refers to a diverse group of diseases characterized by the abnormal extracellular deposition of proteinaceous substances within the body’s organs and tissues. The protein substances are known as amyloid and consist of insoluble fibrils. In general, amyloid deposits arise due to the overproduction of an amyloidogenic protein or as a result of a genetic mutation that occurs in a normally...
Peripheral amyloidosis is a debilitating and often fatal disease. SPECT imaging of amyloid in mice has been established using 125I-SAP. Current efforts are aimed at using125I-labeled synthetic peptides such as p5, which are easier to translate into the clinic in the US since SAP is of human origin. It needs to be shown that the new peptide biomarkers correlate well with the gold standard, SAP. As...
Traditional SPECT imaging requires a trade-off between resolution and sensitivity. We show that it is possible to eliminate this trade-off and come close to achieving both goals simultaneously. Abstractly, small pinhole data is used to improve the resolution of co-registered large pinhole data which has higher sensitivity. Mathematically, the former is used to initialize a set of line processes that...
A detailed GATE model of the Siemens Inveon trimodal platform has been developed. Fully incorporating the PET, SPECT and CT data acquisition subsystems, this model enables feasibility studies of new imaging applications as well as the creation of a baseline against which empirical data can be compared. This paper provides initial validation of the model.
Use of a coded source facilitates high-resolution neutron imaging but requires that the radiographic data be deconvolved. In this paper, we compare direct deconvolution with two different iterative algorithms, namely, one based on direct deconvolution embedded in an MLE-like framework and one based on a geometric model of the neutron beam and a least squares formulation of the inverse imaging problem...
A generic data-driven approach called focus of attention is presented that automatically segments first the projection data and then the image into object and background prior to reconstruction. This segmentation, which is based on the formation of convex hulls, subsequently allows the computational resources to be devoted to the object data while the background data is discarded from further consideration...
Transmission measurements are performed on PET tomographs to create attenuation correction factors for quantitatively accurate images. There are several opportunities within the Inveon Dedicated PET (DPET) to improve the overall performance of the system. The transmission mechanism has a number of characteristics that make it suitable for conebeam-like reconstruction techniques similar to those used...
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