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The effect of ligand pretreatment on human 5-hydroxytryptamine 2C (5-HT 2C ) receptors was examined in CHO cells expressing high (CHO-1C7; 67±3 pmol/mg) or low (CHO-1C19; 72±10 fmol/mg) levels of the receptor. Seventy-two hours pretreatment of CHO-1C7 cells with various ligands did not affect receptor expression. Pretreatment with inverse agonists enhanced 5-HT-mediated inositol phosphate...