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We have investigated by immunohistochemistry the cellular and subcellular distribution of the D1 dopamine receptor (D1R) in the rat striatonigral complex and its relation with the dopaminergic innervation. In the striatum, single pre-embedding immunoperoxidase and immunogold labeling demonstrate that D1R is mainly located on dendritic shafts and spines of spiny dendrites. D1R is also found in association...
Purpose: Dopamine (DA) is a major neurotransmitter in the retina. It is synthesized in amacrine and interplexiform cells projecting to both the inner (IPL) and outer (OPL) plexiform layers. DAergic actions are known to occur through D1 vs D2 receptors, and there is evidence that DA can act at synaptic vs non synaptic sites. So, it was important to localize the two receptor types in the adult and...
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