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Change of actin filament organization at the early stage of cell differentiation directs cell fate commitment of mesenchymal stem cells (MSCs). Thymosin beta‐4 (Tβ4), a major G‐actin sequestering peptide, is known to regulate the cytoskeleton. The study investigated the ways in which Tβ4 regulates cell fate determination in MSCs upon differentiation induction. It was found that Tβ4 decreased F‐actin...
A 78-amino acid insertion (L78) is found in the low-affinity type (L-form) of starch phosphorylase (L-SP, EC 2.4.1.1). This insertion blocks the starch-binding site on the L-SP molecule, and it decreases the binding affinity of L-SP toward starch. The computational analysis of the amino acid sequence on L78 predicts several phosphorylation sites at its Ser residues. Indeed, from the immunoblotting...
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