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Recent findings indicate a pathogenic involvement of IL‐17‐producing CD8+ T cells in multiple sclerosis (MS). IL‐17 production has been attributed to a subset of CD8+ T cells that belong to the mucosal‐associated invariant T (MAIT) cell population. Here, we report a reduction of CD8+ MAIT cells in the blood of MS patients compared with healthy individuals, which significantly correlated with IL‐18...
It is estimated that 30–100million people are infected with the pathogenic nematode Strongyloides stercoralis worldwide but parasite control is still based on anti-helminthic treatment. To develop protective vaccination strategies, we use the murine model of Strongyloides ratti infection. We have shown recently that vaccination with alum-precipitated, but not with native or CFA-emulsified S. ratti...
The control of strongyloidiasis affecting approximately 100 million people – caused by the gastrointestinal nematode Strongyloides stercoralis – is still based on anti-helminthic treatment. In the current study we analysed the immune response to Strongyloides ratti heat shock protein 60 (srHSP60) as a possible vaccine candidate in the murine system. We show that srHSP60 is a target of both, humoral...
The transmembrane glycoprotein CD83 is rapidly upregulated on murine and human DC upon maturation and therefore a costimulatory function for T cell activation has been suggested. Studies employing human APC indeed showed that CD83 expression was positively correlated to the stimulatory capacity of the APC. Murine APC that were CD83 deficient however, did not display a reduced capacity to activate...
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