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In the last 50 years, nucleoside analogs have been introduced to drug therapy as antivirals for different types of cancer due to their interference in cellular proliferation. Among the first line of nucleoside treatment drugs, ribavirin (RBV) is a synthetic N‐nucleoside with a 1,2,4‐triazole moiety that acts as a broad‐spectrum antiviral. It is on the World Health Organization (WHO) list of essential...
The decarboxylation of amino acids in presence of a carboxylic anhydride leading to the corresponding ketones, known as Dakin-West reaction, is about to complete almost one century of discovery. In this review, we firstly present the chronological progress in the mechanistic study of the reaction, with an overview about types of substrates, anhydrides and bases already used in the Dakin-West reaction...
Despite the technological knowledge available for thousands years about fermentation processes, interestingly only in the last two hundred years scientists have developed tools that allow chemists to use the natural power of biocatalysts in the laboratory. The present review has covered the literature from 1991 to 2012 with the most exciting examples of lipase-catalyzed reactions under continuous...
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