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Studies were performed to investigate the relationship between heat shock protein (HSP) and the acquired resistance to uranyl acetate (UA)-induced acute renal failure (ARF). Rats were resistant to a rechallenge with 5 mg/kg of UA between 1 and 2 weeks after the first injection of the same amount of UA. During this period, the renal HSP73 was increased to 148 ± 12% of baseline, and tubular damage...