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Prolonged over-exposure of rats to corticosterone attenuates 5-HT 1A -receptor-mediated responses in hippocampal CA1 cells through an unknown mechanism, not involving downregulation of 5-HT 1A receptor expression. We here tested if corticosterone changes 5-HT 1A receptor function indirectly, by altering hippocampal mRNA expression of NCAM, SGK1, or RGS4, which all modulate...
Axonal sprouting and synaptic reorganization play an important role in the adaptation of the CNS to injury. However, the molecular mechanisms underlying this neuronal plasticity are poorly understood. In the present study we used in situ hybridization to examine the expression of NCAM mRNA in normal hippocampus, and in response to entorhinal cortex (EC) lesions and transient global ischemia. Both...
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