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CDH1 mutation carriers have a strongly increased risk of developing gastric cancer (GC) and lobular breast cancer (LBC). Clinical data of GC cases and surgical and histological data of prophylactic gastrectomies and mastectomies of all 10 Dutch CDH1 mutation families were collected. In vitro functional assays were performed to analyze the nature of the newly found missense mutation c.1748T>G (p...
Prolonged over-exposure of rats to corticosterone attenuates 5-HT 1A -receptor-mediated responses in hippocampal CA1 cells through an unknown mechanism, not involving downregulation of 5-HT 1A receptor expression. We here tested if corticosterone changes 5-HT 1A receptor function indirectly, by altering hippocampal mRNA expression of NCAM, SGK1, or RGS4, which all modulate...
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