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Background Susceptibility to beryllium (Be)-hypersensitivity (BH) has been associated with HLA-DP alleles carrying a glutamate at position 69 of the HLA-DP β-chain (HLA-DPGlu69) and with several HLA-DP, -DQ and -DR alleles and polymorphisms. However, no genetic associations have been found between BH affected subjects not carrying the HLA-DPGlu69 susceptibility marker. Methods In this report, we...
Berylliosis is a chronic granulomatous disorder caused by inhalation of Be dusts that is driven by the accumulation Be-specific CD4+ Th1-cells at disease sites. Susceptibility to berylliosis has been associated with the supratypic variant of HLA-DP gene coding for glutamate at position β69 (HLA-DPβGlu69). The aim of this study was to test the hypothesis that the HLA-DPβGlu69 residue plays a role in...
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