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We identified the transfer functions relating beat-to-beat fluctuations in arterial blood pressure to maximal ventricular elastance (ABPrarrEmax) and beat-to-beat fluctuations in heart rate to Emax (HRrarrEmax) to characterize the dynamic properties of the arterial ventricular contractility baroreflex and force-frequency relation, respectively, in three conscious dogs before and after pacing-induced...
We performed a pilot investigation of the cardiopulmonary baroreflex control of ventricular contractility in two conscious dogs. We specifically measured spontaneous beat-to-beat hemodynamic variability before and after the administration of propranolol. We then identified the transfer function relating beat-to-beat fluctuations in central venous pressure (CVP) to maximal ventricular elastance (Emax...
To examine the effects of heart failure on beat-to beat arterial blood pressure (ABP) variability, four adult mongrel dogs (20-25 kg) were chronically instrumented for ventricular pacing and continuous measurements of central ABP and cardiac output (CO). Five minutes recordings with the dogs conscious and at rest took place after recovery from surgery (control) and after a 30 days long period of pacing...
We have previously proposed a technique for estimating the static gain values and impulse response of the arterial and cardiopulmonary total peripheral resistance (TPR) baroreflex by mathematical analysis of beat-to-beat fluctuations in arterial blood pressure, cardiac output, and stroke volume. In this study, we evaluated the technique with respect to spontaneous hemodynamic variability measured...
Left ventricular ejection fraction (EF) is perhaps the most clinically significant index of global ventricular function. EF is measured in clinical practice via imaging methods such as echocardiography. However, these methods generally require a well-trained operator and expensive capital equipment. Thus, EF measurements are only obtained in the clinical setting and are usually made few and far between...
We have previously proposed a potentially non-invasive technique for determining the closed-loop gain values of the arterial and cardiopulmonary total peripheral resistance (TPR) baroreflex systems by mathematical analysis of beat-to-beat fluctuations in arterial blood pressure, cardiac output, and stroke volume. In this paper, we describe an evaluation of the technique with respect to spontaneous...
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