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A major obstacle for understanding the molecular basis of root nodule morphogenesis has been for many years the lack of a well-developed genetic system in a legume that is amenable to the advanced technologies developed for model plants such as Arabidopsis thaliana. The diploid self-fertile plant Lotus japonicus has been identified and exploited as model legume by the research community and is now...
Loss of the tumor suppressor merlin causes development of the tumors of the nervous system, such as schwannomas, meningiomas, and ependymomas occurring spontaneously or as part of a hereditary disease Neurofibromatosis Type 2 (NF2). Current therapies, (radio) surgery, are not always effective. Therefore, there is a need for drug treatments for these tumors. Schwannomas are the most frequent of merlin‐deficient...
Cofilin is a small protein that belongs to the family of actin-depolymerizing factors (ADF). The main cellular function of cofilin is to change cytoskeletal dynamics and thus to modulate cell motility and cytokinesis. We have recently demonstrated that the actin cytoskeleton is involved in the modulation of Ca 2+ signalling in starfish oocytes. To extend these observations, we have explored...
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